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Color etching of a milkmaid showing her cowpoxed hand to Jenner, while a portly physician tempts a dandy with inoculation, ca. 1800.

Featured on PDR in the essay “The Mark of the Beast”: Georgian Britain’s Anti-Vaxxer Movement

Ox-faced children, elderly women sprouting horns, and cloven minds — all features attributed to Edward Jenner’s vaccine against smallpox. Introducing us to the original anti-vaxxers, Erica X Eisen explores the “vacca” in the first-ever vaccine: its bovine origins and the widespread worry that immunity came with beastly side effects.